303. Eric Yuk Fai Wan, Sukriti Mathur, etc., Association of COVID-19 with short- and long-term risk of cardiovascular disease and mortality: a prospective cohort in UK Biobank, 2023.01.19, https://academic.oup.com/cardiovascres/advance-article/doi/10.1093/cvr/cvac195/6987834 . COVID-19 infection, including long-COVID, is associated with increased short- and long-term risks of CVD and mortality. Ongoing monitoring of signs and symptoms of developing these cardiovascular complications post diagnosis and up till at least a year post recovery may benefit infected patients, especially those with severe disease.

302. Dana A Glei, The US Midlife Mortality Crisis Continues: Excess Cause-Specific Mortality During 2020, 2022.03.24, https://academic.oup.com/aje/article/191/10/1677/6553935 . Whether monthly excess mortality in the United States during 2020 varied by age and cause of death is investigated in this analysis. Drug-related deaths may be driving the increase in external mortality, but drug overdoses were already increasing for a full year before the pandemic. The oldest Americans bore the brunt of COVID-19 deaths, but working-age Americans, particularly men, suffered substantial numbers of excess non-COVID deaths, most commonly from external causes and heart disease.

301. Andrew Tiu, Zachary Susswein, etc., Characterizing the Spatiotemporal Heterogeneity of the COVID-19 Vaccination Landscape, 2022.04.27, https://academic.oup.com/aje/article/191/10/1792/6574722 . As variants of SARS-CoV-2 have emerged throughout 2021–2022, the need to maximize vaccination coverage across the United States to minimize severe outcomes of COVID-19 has been critical. Using a comparison with a mechanistic growth model fitted to our integrated data, we classified vaccination dynamics across time at the county scale. Our findings underline the importance of curating accurate, fine-scale vaccination data and the continued need for widespread vaccination in the United States, especially with the continued emergence of highly transmissible SARS-CoV-2 variants.

300. Mohammed Noushad, Mohammed Sadeg Al-Awar, etc., Lack of Access to Coronavirus Disease 2019 Vaccines Could Be a Greater Threat than Vaccine Hesitancy in Low-Income and Conflict Nations: The Case of Yemen, 2022.02.02, https://academic.oup.com/cid/article/75/10/1827/6520556 . We conducted a nation-wide cross-sectional survey among the general population in Yemen, a low-income conflict country. Overall, 50.1% of the 5329 respondents agreed to accept a COVID-19 vaccine and only 39.9% of participants agreed that they had access to a COVID-19 vaccine, with females indicating lower access than males. Overall, 50.1% of the 5329 respondents agreed to accept a COVID-19 vaccine. Only 39.9% of participants agreed that they had access to a COVID-19 vaccine, with females indicating lower access than males.

299. Saoussen Ben Abdallah, Yosra Mhalla, etc., Twice-Daily Oral Zinc in the Treatment of Patients With Coronavirus Disease 2019: A Randomized Double-Blind Controlled Trial, 2022.11.04, https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciac807/6795268?searchresult=1 . Zinc supplementation has been considered a potential therapy for COVID-19. We aimed to examine zinc efficacy in adult patients with COVID-19 infection. We conducted a prospective, randomized, double-blind, placebo-controlled multicenter trial, and found that, in COVID-19 patients, oral zinc can decrease 30-day death, ICU admission rate and can shorten symptom duration.

298. Faris Chalali, Marie Merlant, etc., Histological Features Associated With Human Monkeypox Virus Infection in 2022 Outbreak in a Nonendemic Country, 2022.11.01, https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciac856/6787607 . Skin histology of papules and pustules from 5 men having sex with men with Monkeypox infection showed viral intracytoplasmic cytopathic changes, interface dermatitis, marked inflammatory dermic infiltrate including superficial neutrophils and perivascular and periadnexal deep lymphocytes. Histologic description of Monkeypox lesions improves our understanding about clinical presentations and may have some therapeutic implications.

297. Ann E Woolley, Scott Dryden-Peterson, etc., At-home Testing and Risk Factors for Acquisition of SARS-CoV-2 Infection in a Major US Metropolitan Area, 2022.10.05, https://academic.oup.com/ofid/article/9/11/ofac505/6748960 . Unbiased assessment of the risks associated with acquisition of SARS-CoV-2 is critical to informing mitigation efforts during pandemics. The objective of our study was to understand the risk factors for acquiring COVID-19 in a large prospective cohort of adult residents in a large US metropolitan area. These results demonstrate that race/ethnicity and socioeconomic status are the biggest determinants of acquisition of infection.

296. Lucy Bray, Katerina Meznikova, etc., Misdiagnoses in the Context of Suspected Pandemic Influenza or Coronavirus Disease 2019: A Systematic Review, 2022.10.05, https://academic.oup.com/ofid/article/9/11/ofac515/6748966 . There have been numerous reports of patients initially misdiagnosed in the 2009 H1N1 influenza and COVID-19 pandemics within the literature. We identified 686 cases of misdiagnosis, categorized as viral respiratory infection, other respiratory infection, non-respiratory infection, and non-infective. Further research is required to understand why misdiagnoses occur and harm arises and how clinicians can be assisted in their decision making in a pandemic context.

295. Helen M Chun, Kyle Milligan, etc., A Systematic Review of COVID-19 Vaccine Antibody Responses in People With HIV, 2022.11.08, https://academic.oup.com/ofid/article/9/11/ofac579/6811510 . We summarize COVID-19 vaccine responses in people with HIV (PWH). A systematic literature review of studies from January 1, 2020, to March 31, 2022, of COVID-19 vaccine immunogenicity in PWH from multiple databases was performed. While 22 (73%) studies reported high COVID-19 vaccine seroconversion rates in PWH, PWH with lower baseline CD4 counts, CD4/CD8 ratios, or higher baseline viral loads had lower seroconversion rates and immunologic titers. Data on vaccine-induced seroconversion in PWH are reassuring, but more research is needed to evaluate the durability of COVID-19 vaccine responses in PWH.

294. Joshua A Barocas, Steffanie A Strathdee, etc., Beyond Sex: Human Monkeypox Virus is an Emerging Threat to Marginalized Populations, 2022.10.17, https://academic.oup.com/ofid/article/9/11/ofac551/6761765 . People experiencing homelessness and those with substance use disorders are vulnerable to MPXV. People with substance use disorders, specifically those who inject drugs, are at increased risk due to lack of access to sterile injection equipment. We present a spectrum of structural determinants underpinning increased risks in these populations and recommendations that could help mitigate the spread.

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