30.
Prabhu S. Arunachalam, Florian Wimmers, Chris Ka Pun Mok, Ranawaka A. P. M. Perera,
Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans, 2020.08.11,
https://science.sciencemag.org/content/early/2020/08/10/science.abc6261 .
This article analyes immune responses in 76 COVID-19 patients and 69 healthy individuals and the results highlight molecules such as EN-RAGE or TNFSF14, and their receptors, which could represent attractive therapeutic target against COVID-19.
29.
Pedro M Folegatti, Katie J Ewer, Parvinder K Aley, Brian Angus, Prof Stephan Becker, Sandra Belij-Rammerstorfer, et al.,
Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial, 2020.07.20,
https://doi.org/10.1016/S0140-6736(20)31604-4 .
ChAdOx1 nCoV-19 showed an acceptable safety profile, and homologous boosting increased antibody responses. These results, together with the induction of both humoral and cellular immune responses, support large-scale evaluation of this candidate vaccine in an ongoing phase 3 programme.
28.
Feng-Cai Zhu, Xu-Hua Guan, Yu-Hua Li, Jian-Ying Huang, Tao Jiang, Li-Hua Hou, et al.,
Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, phase 2 trial, 2020.07.20,
https://doi.org/10.1016/S0140-6736(20)31605-6 .
This study shows that the Ad5-vectored COVID-19 vaccine at 5 × 1010 viral particles is safe, and induced significant immune responses in the majority of recipients after a single immunisation.
27.
Christine M Salvatore, Jin-Young Han, Karen P Acker, Priyanka Tiwari, Jenny Jin, Michael Brandler, et al.,
Neonatal management and outcomes during the COVID-19 pandemic: an observation cohort study, 2020.07.23,
https://doi.org/10.1016/S2352-4642(20)30235-2 .
this report suggests that perinatal transmission of COVID-19 is unlikely to occur if correct hygiene precautions are undertaken, and that allowing neonates to room in with their mothers and direct breastfeeding are safe procedures when paired with effective parental education of infant protective strategies.
26.
Long H Nguyen, David A Drew, Mark S Graham, Amit D Joshi, Chuan-Guo Guo, Wenjie Ma, et al. ,
Risk of COVID-19 among front-line health-care workers and the general community: a prospective cohort study, 2020.07.31,
https://doi.org/10.1016/S2468-2667(20)30164-X .
In the UK and the USA, risk of reporting a positive test for COVID-19 was increased among front-line health-care workers. Health-care systems should ensure adequate availability of PPE and develop additional strategies to protect health-care workers from COVID-19, particularly those from Black, Asian, and minority ethnic backgrounds. Additional follow-up of these observational findings is needed.
25.
Ying Zhou, Renzhe Xu, Dongsheng Hu, Yang Yue, Qingquan Li, Jizhe Xia,
Effects of human mobility restrictions on the spread of COVID-19 in Shenzhen, China: a modelling study using mobile phone data, 2020.08.01,
https://doi.org/10.1016/S2589-7500(20)30165-5 .
this study shows the effects of various types and magnitudes of mobility restrictions on controlling COVID-19 outbreaks at the city level in Shenzhen, China.
24.
Matthieu Schmidt, David Hajage, Guillaume Lebreton, Antoine Monsel, Guillaume Voiriot, David Levy, et al.,
Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome associated with COVID-19: a retrospective cohort study, 2020.08.13 ,
https://doi.org/10.1016/S2213-2600(20)30328-3 .
The estimated 60-day survival of ECMO-rescued patients with COVID-19 was similar to that of studies published in the past 2 years on ECMO for severe ARDS. If another COVID-19 outbreak occurs, ECMO should be considered for patients developing refractory respiratory failure despite optimised care.
23.
Noa Biran, Andrew Ip, Jaeil Ahn, Ronaldo C Go, Shuqi Wang, Shivam Mathura, et al.,
Tocilizumab among patients with COVID-19 in the intensive care unit: a multicentre observational study, 2020.08.14,
https://doi.org/10.1016/S2665-9913(20)30277-0 .
In this observational study, patients with COVID-19 requiring ICU support who received tocilizumab had reduced mortality.
22.
Cédric Cotter,
From the ‘Spanish Flu’ to COVID-19: lessons from the 1918 pandemic and First World War, 2020.04.23 ,
https://blogs.icrc.org/law-and-policy/2020/04/23/spanish-flu-covid-19-1918-pandemic-first-world-war/ .
There are hard-won lessons from the ‘Spanish Flu’, and similarities with the COVID-19 crisis, that merit reflection on how armed conflicts can influence the ways we talk about and struggle to mitigate the current pandemic.
21.
Ching-Lin Hsieh, Jory A. Goldsmith, Jeffrey M. Schaub, Andrea M. DiVenere, Hung-Che Kuo,
Structure-based design of prefusion-stabilized SARS-CoV-2 spikes, 2020.07.23 ,
https://science.sciencemag.org/content/early/2020/07/22/science.abd0826 .
this study identified HexaPro, whose A 3.2 Å-resolution cryo-EM structure confirmed that it retains the prefusion spike conformation. High-yield production of a stabilized prefusion spike protein will accelerate the development of vaccines and serological diagnostics for SARS-CoV-2.
Chinese Society of International Law, in association with Chinese Institute of International Law at China Foreign Affairs University, and National Center for Foreign-related Rule of Law Research at China Foreign Affairs University
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